Theranostics of triple negative breast cancer: a review

INTRODUCTION: Triple negative cancer is one of the most aggressive subtypes breast cancer. Currently, no effective treatment methods have been proposed that would significantly affect long-term results treatment. OBJECTIVE: To summarize possibilities theranostics and nanteranostics in visualization elimination malignant cells immunosuppressive microenvironment thriple MATERIALS AND METHODS: A search was conducted for scientific publications PubMed information analytical system 2015–2022 by keywords: «triple cancer» («triple cancer»), «signaling pathways» («signaling pathways»), «tumor microenvironment» («tumor microenvironment»), «cancer stem cells» («stem tumor cells»), «theranostics», «nanomaterials» («nanomaterials»), «nanotheranostics» («nanoteranostics»). After excluding articles devoted to technical aspects molecular biological research, 57 related thrice-negative were analyzed. RESULTS: Targets triple are associated with components microenvironment. The article presents data on composition interaction between various cellular subpopulations microenvironment, as well role its formation. State art classifications defects presented. stem, differentiated described. authors present their own nature distribution which should be taken into account when choosing effect tumor. applications radiopharmaceuticals nanoparticle-based preparations developed date CONCLUSION: characterized presence a large number biomarkers can targets diagnostic therapeutic drugs. It advisable use artificial intelligence technologies selection. nanoparticles makes it possible reduce toxicity ensure implementation several simultaneously.